Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	# of Subjects	# of Subjects	
General	Clinical Center	8676	1843	938	
	Ethnicity	8676	1843	938	
	FDR Status	8676	1843	938	
	HLA Genotypes	8676	1843	938	
	Maternal Education	1611	220	166	
	Race	8676	1843	938	
	Sex	8676	1843	938	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	# of Subjects	# of Subjects	
Endpoints	Celiac Disease Endpoint	8676	1843	938	
	T1D Endpoint	8676	1843	938	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	# of Subjects	# of Subjects	
First Mother Questionnaire	Alcohol consumption during pregnancy	8526	1835	932	
	Body measurements before and end of pregnancy	8512	1834	931	
	Dietary supplements during pregnancy	8526	1835	932	
	Employment during pregnancy	8524	1835	932	
	Food intake during pregnancy	8526	1835	932	
	Illnesses/conditions during pregnancy	8526	1835	932	
	Medications during pregnancy	8526	1835	932	
	Mother's history of diabetes	8526	1835	932	
	Perception of child's future	8510	1832	931	
	Perception of child's risk	8515	1834	932	
	Perception of genetic testing	8516	1835	932	
	Psychological adjustment during pregnancy	8461	1828	930	
	Smoking status during pregnancy	8519	1835	932	
	Special diets during pregnancy	8526	1835	932	
	Water consumption during pregnancy	8505	1831	930	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	# of Subjects	# of Subjects	
First Father Questionnaire	Perception of child's future	8017	1779	911	
	Perception of child's risk	8021	1780	911	
	Perception of genetic testing	8019	1780	911	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	# of Subjects	# of Subjects	
Primary Caretaker Interview Forms 1	Animals or pet exposure	7577	1824	923	
	Apgar score	8670	1843	938	
	Child life experiences	8668	1841	938	
	Country of birth	7553	1819	921	
	Diet	8671	1843	938	
	Dietary supplements	8671	1843	938	
	Education	7568	1822	922	
	Employment	7578	1824	923	
	First language	7552	1819	921	
	Hospitalization	8671	1843	938	
	Infant milk intake	8671	1843	938	
	Life experiences	8668	1840	938	
	Living arrangements	7578	1824	923	
	Location	7565	1822	922	
	Marital status	7565	1822	922	
	Medical conditions	8671	1843	938	
	Medications	8668	1843	938	
	Mode of delivery	8669	1843	938	
	Number of children in household	7569	1822	921	
	Number of rooms in household	7553	1819	920	
	Primary Caretaker's body measurements	3737	801	502	
	Smoking status	7579	1824	923	
	Subject's birth measurements	8671	1843	938	
	Water consumption	8670	1842	937	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	# of Subjects	# of Subjects	
Family History Questionnaire 2	Family member's history of autoimmune disease(s)	7462	1807	917	
	Family member's history of diabetes	7466	1811	919	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	# of Subjects	# of Subjects	
Diagnosis of Diabetes Form	Body measurements	430	111	111	
	Laboratory values at time of diagnosis (e.g. pH, glucose, glycosylated hemoglobin, potassium, sodium)	455	113	113	
	Symptoms (e.g. weight loss, polydipsia)	455	113	113	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	
Physical Examination Form 3	Additional study participation	8409	23	1828	14	930	14	
	Blood draw details	8668	23	1843	15	938	14	
	Body measurements	8638	23	1843	15	938	14	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	
TEDDY Book Data Extraction Forms 3	Acute/chronic illnesses	8178	24	1842	14	937	13	
	Allergies	8178	24	1842	14	937	13	
	Body measurements	7320	4	1722	4	874	4	
	Child's/Parent's life experiences	8176	24	1842	14	937	13	
	Dietary supplements	8180	24	1842	14	937	13	
	Early diet exposures	8116	14	1842	14	937	13	
	Hospitalizations	8178	24	1842	14	937	13	
	Introduction to foods	8085	6	1841	7	936	7	
	Medications	8177	24	1842	14	937	13	
	Social groups (e.g. daycare, school)	8178	24	1842	14	937	13	
	Special diets	8177	24	1842	14	937	13	
	Vaccinations	8179	24	1842	14	937	13	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	
Symptoms of Celiac Disease Tracking Form 4	Symptoms (e.g. vomiting, fatigue, abdominal discomfort, irritability)	6446	9	1583	2	806	2	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	
TEDDY Annual Questionnaire 5	Diabetes prevention	7237	9	1787	4	900	3	
	Emotional state	7235	9	1787	4	900	3	
	Monitoring diabetes risk	7235	9	1787	4	900	3	
	Perception of TEDDY study	7236	9	1787	4	900	3	
	Perception of child's future	7231	9	1784	4	897	3	
	Perception of child's risk	7237	9	1787	4	900	3	

	Full Cohort	
	# of Subjects	Average # of Time Points	
Annual Child Questionnaire 6	Diabetes prevention	4807	3	
	Parental diabetes prevention	4809	3	
	Perception of TEDDY study	4808	3	
	Perception of diabetes risk	4806	3	
	State-Trait Anxiety Inventory (STAI)	4809	3	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	
Gluten-free Diet Annual Update Form 5	Consumption of food containing gluten	1176	7	79	2	38	2	
	Diet counseling	1174	7	80	2	38	2	
	Exposure to oats	1176	7	79	2	38	2	
	Gluten-free diet	1176	7	79	2	38	2	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	
Psychosocial Forms	Child Strengths and Difficulties Questionnaire 7	4508	2	0	0	0	0	
	Child behavior checklist 8	5608	3	1227	2	527	2	
	Parent Strengths and Difficulties Questionnaire 7	4651	3	0	0	0	0	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	
Additional Data Collected	24-Hour and 3-Day Diet Records	8647	12	1840	9	936	8	
	Physical Activity Assessment	4757	4	240	1	94	1	
	Tanner Stage 9	5425	10	0	0	0	0	

	Full Cohort	1:3 Case-Control	1:1 Case-Control	
	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	# of Subjects	Average # of Time Points	
Sample Data Collected	IA (GADA, IA2A, MIAA)	8648	23	1843	15	938	14	
	OGTT	472	8	8	2	8	2	
	Salivary Cortisol	5041	2	1076	2	462	2	
	TSH	648	2	0	0	0	0	
	TgA	7007	13	1738	4	862	3	
	Thyroid antibodies	5699	3	0	0	0	0	
	ZnT8A	5468	13	613	1	400	1